Erosive Esophagitis (EE)

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EE affects approximately 20 million people

EE is more than just heartburn

EE is a type of acid reflux in which the lining of the esophagus is damaged by stomach acid. Approximately 20 million people in the US have EE. Many people with EE continue to feel acid in their esophagus despite taking medicines.

Nearly 58% of people suffering from EE still experience heartburn while on their treatment


Not all treatments work for everyone. It’s important to talk to your doctor about treatments that are right for you. If you think you might have EE, know that you’re not alone. EE is more than just heartburn and if left untreated it can lead to serious complications.

The history of EE and its treatments

  • 1977 The first histamine blocker was approved for use
  • 1989 The first proton-pump inhibitor was approved for use
  • 2023 VOQUEZNA (vonoprazan) was approved for use as the first potassium-competitive acid blocker
  • Histamine blockers (H2s)

    H2s treat EE by reducing the amount of acid produced by the stomach. They work by blocking one of the first steps in acid production.

  • Proton pump inhibitors (PPIs)

    PPIs are used to treat EE and symptoms. They work by reducing the amount of acid the stomach produces. Most of these medications need to be taken with food.

  • Potassium-competitive acid blocker (PCAB)

    VOQUEZNA is approved to treat EE and related heartburn. VOQUEZNA does not need to be taken with food.

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How is EE diagnosed?

To diagnose EE, your doctor will ask you a few questions, perform a physical exam, and order an endoscopy. An endoscopy is a procedure in which a thin tube equipped with a tiny camera is lowered down your throat. Sometimes, small tissue samples are taken during an endoscopy and sent to a lab for testing. An endoscopy will help your doctor to determine if your symptoms are caused by EE or some other condition.

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Who does EE affect?

EE affects all types of people, but there are certain risk factors, such as:

  • Hiatal hernia
  • Obesity
  • Lower esophageal sphincter doesn’t close correctly
  • Delayed stomach emptying

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The most common symptoms are heartburn and acid regurgitation. Other possible signs of EE include:

  • Difficult or painful swallowing
  • Chronic cough
  • Chest pain

Talk to your doctor
about a different option

If you’re still searching for a way to control EE, use our doctor discussion guide to help talk to your doctor about VOQUEZNA.